Microsoft has acknowledged a known issue with Windows Server 2016 and Exchange Server 2016, and has advised not to deploy this configuration for now.
Get-MailboxDatabaseCopyStatus Displays Incorrect Activation Preference Value
In Exchange Server the Get-MailboxDatabaseCopyStatus cmdlet may return the wrong activation preference value for a database copy.
Unable to Move Mailboxes to an Exchange Server 2013 Database that is Excluded from Provisioning
When moving an Exchange 2013 mailbox to a database that is excluded from provisioning you receive an error.
Critical Issue with Litigation Hold in Exchange Server 2013 and Office 365
A critical issue has been reported with the behavior of litigation hold in Exchange Server 2013 and Office 365.
More Hybrid Issues for Exchange Server 2013 with Cumulative Update 6
New bugs have appeared in Exchange Server 2013 Cumulative Update 6 impacting Hybrid customers.