Microsoft has published guidance for Exchange Server and Office 365 customers for the Spectre and Meltdown processor vulnerabilities.
Don't Deploy Exchange Server 2016 on Windows Server 2016 For Now Due to Stability Issues
Microsoft has acknowledged a known issue with Windows Server 2016 and Exchange Server 2016, and has advised not to deploy this configuration for now.
Beware of Bad Advice About Exchange Servers and Windows Firewall
You should not disable the Windows Firewall on Exchange servers.
Exchange Server 2010 to 2013 Migration – Managing a Co-Existence Environment
How to use the Exchange Server management tools to administer a co-existence environment.
Exchange Server 2010 to 2013 Migration – Installing Exchange Server 2013
Installing the first Exchange 2013 servers into an existing Exchange 2010 organization.