Microsoft has published guidance for Exchange Server and Office 365 customers for the Spectre and Meltdown processor vulnerabilities.
Microsoft has acknowledged a known issue with Windows Server 2016 and Exchange Server 2016, and has advised not to deploy this configuration for now.
You should not disable the Windows Firewall on Exchange servers.
How to use the Exchange Server management tools to administer a co-existence environment.
Installing the first Exchange 2013 servers into an existing Exchange 2010 organization.