I was doing a little cleanup of the C: drive on a server that was unfortunately created with too small a volume size. One of the things I deleted was all of the files and subfolders in the Temp folder of my user profile. A few minutes later I launched the System Center Essentials 2007 console and was greeted with this error.
Could not find a part of the path “C:Documents and SettingsusernameLocal SettingsTemp2
The “2” folder was created because you’re logged in via RDP. Each session gets its own temp dir so they don’t step on each other.